March 14, 2012

HELIX BIOPHARMA CORP. ANNOUNCES AGREED CHANGES TO THE BOARD OF DIRECTORS AND SETTLEMENT WITH CONCERNED SHAREHOLDERS

AURORA, ON–(Marketwire – March 14, 2012) – Helix BioPharma Corp. (TSX: HBP) (NYSE Amex: HBP) (FRANKFURT: HBP) (the “Company” or “Helix”) announces that it has settled the proxy contest with the Concerned Shareholders named in the Dissident Proxy Circular dated January 13, 2012, in connection with the Company’s Annual General Meeting held on January 30, 2012, and agreed on a reconstituted Board of Directors of Helix. As a result of the settlement, Messrs. Segal, Docherty, Cawkell, Lickrish, and Roszkowski-Sliz will resign from the board of directors and be replaced by William White, Robert Verhagen, Marek Orlowski and Mario Gobbo whose biographies were described in the Dissident Proxy Circular. Jack Kay and W. Thomas Hodgson will continue on the Board and have agreed to support the appointment of Mr. William White as the new Chairman of the Board.