August 23, 2012
(Aurora, Ontario) – Helix BioPharma Corp. (TSX, FSE: “HBP”), a biopharmaceutical company developing
drug candidates for the prevention and treatment of cancer, today announced that it has applied to the
Toronto Stock Exchange to extend the expiry date of the 2009 Warrants (as defined below) by six months,
from September 7, 2012 at 5:00 p.m. (Toronto time) (the “Current Expiry Date”) to March 7, 2013 at 5:00
p.m. (Toronto time). Helix does not propose to amend any other provision of the 2009 Warrants, and none of
the 2009 Warrants is held directly or indirectly by an insider of Helix.