DOS47 – A broad anti-cancer antibody drug conjugate (ADC) platform
DOS47 is based upon a naturally occurring enzyme isolated from the jack bean plant called urease that breaks down a natural substance found in the body, urea, into metabolites that include ammonium and hydroxyl ions. By doing so at the site of cancerous tissues in the body, the Company believes DOS47 can modify the tumor micro environmental conditions that could potentially lead to apoptosis of the cancer cells (programmed cell death).
DOS47 – A patented ADC platform technology offers a new and potentially revolutionary approach to the destruction of cancer destruction of cancer cells
DOS47 is designed to stimulate an increase in the pH of the microenvironment surrounding the cancerous cells, effectively reversing the acidic extra cellular conditions that are believed to act to defend the tumour. The local production of ammonia at the site of cancerous tissues is thought to readily diffuse into the cancer cells to exert a potent cytotoxic effect by interfering with their critical metabolic functions.
DOS47 – Theoretical Mode of Action (2008)
DOS47 – Confirmed Mechanism of Action (2016)
Interview With The Inventor of DOS47 (2019)
Helix believes that DOS47 may have applications both as a monotherapy and in certain combinations with chemo-, radio-, and IO therapies
L-DOS47 is the Company’s first targeted therapeutic ADC immunoconjugate under development based on the DOS47 technology. L-DOS47 is an antibody protein conjugate where the urease component enzymatically converts naturally occurring urea to ammonia. The L-DOS47 drug molecule includes a highly specialized camelid-derived single domain antibody against CEACAM6 and is currently under clinical study for the treatment of pancreatic cancer. the L-DOS47 can be further expanded in other tumor types with high expression of CEACAM6 serving as a ADC platform across multiple cancers.
Helix continues to explore opportunities to expand upon its product pipeline with new DOS47 based therapeutics
DOS47 candidates are produced by conjugating urease with a targeting antibody or antibody fragment that can specifically direct the urease to the surface of a cancer cell. Once docked to the cell, the urease produces ammonia enzymatically through the conversion of urea found throughout the body. These conjugates of antibodies to urease are called DOS47 candidates. By selecting antibodies that are selective to different tumour cell surface receptors, the Company believes that DOS47 candidates can be used in several types of solid tumors.