Helix BioPharma Corp. Announces Leadership Transition

Aurora, Ontario – September 18, 2015 – Helix BioPharma Corp. (TSX, FSE: “HBP”), a biopharmaceutical company developing innovative drug candidates for the prevention and treatment of cancer, today announced that Robert Verhagen has resigned as President and Chief Executive Officer (CEO), effective as of November 1, 2015, and as a member of the Board of Directors, effective immediately. Mr. Verhagen will continue to serve as CEO to assist in the Company’s management transition and he has been with Helix since 2012. In the event that the Board has not appointed a new Chief Executive Officer by November 1, 2015, Helix’s Board of Directors intends to appoint Yvon Bastien, Chairman of the Board, to assume the role of President and Chief Executive Officer on an interim basis.